t cell immune responses in psoriasis.

نویسندگان

zohre jadali department of immunology, school of public health, tehran university of medical sciences, tehran, iran.

mohammad bagher eslami department of immunology, school of public health, tehran university of medical sciences, tehran, iran.

چکیده

a central role for t cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. the goal of this study is to summarise currently available data on the importance of t cells in psoriasis pathogenesis. a  systematic  review  of  the  english  medical  literature  was  conducted  by  searching pubmed, embase, isi web of knowledge, and iranian databases including iranmedex, and sid for studies on associations between the involvement of t cell subsets and psoriasis. the results of the present study indicate that alterations in the number and function of different subsets of t-cells are associated with psoriasis. it   appears   that   studies   on   t   cell   subsets   contributed   to   understanding   the immunopathogenesis  of  psoriasis.  in  addition,  it  may  have  provided  novel  therapeutic opportunities in ameliorating immunopathologies.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

T cell immune responses in psoriasis.

A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis. A systematic review of the English medical literature was conducted by searching PubMed, Embase, ISI Web of Knowl...

متن کامل

T-cell immune responses in Mycobacterium avium-infected mice.

Mycobacterium avium infection was substantially more severe in C57BL/6 (Bcgs) than in (C57BL/6 x DBA/2)F1 hybrid (Bcgr) mice both in terms of bacterial growth in the spleens and lungs and in host survival. Prior Mycobacterium bovis BCG vaccination resulted in increased resistance as well as enhanced tuberculin hypersensitivity to both PPD-S (Mycobacterium tuberculosis) and PPD-A (M. avium). Mic...

متن کامل

γδ T Cell-Mediated Immune Responses in Disease and Therapy

The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that express a distinct T cell receptor (TCR) composed of γδ chains instead of αβ chains. Unlike αβ T cells, γδ T cells display a restricted TCR re...

متن کامل

Immune monitoring of T-cell responses in cancer vaccine development.

Monitoring cellular immune responses is one prerequisite for rational development of cancer vaccines. The primary objective of immune monitoring is to determine the efficacy of a vaccine to induce or augment a specific T-cell response. Further questions relate to the prevalence and functional relevance of spontaneous tumor-directed immune responses, the functional characteristics of T-cell resp...

متن کامل

T Cell Mediated Immune Responses Against Mycobacterium Tuberculosis

One-third of the world’s population is estimated to be infected with Mycobacterium tuberculosis (M. tuberculosis) and remains asymptomatic. Of these, only 5-10% of the individuals are known to develop active tuberculosis in their lifetime. Host T cell mediated adaptive immune responses are of critical importance against M. tuberculosis infection. However the immune mechanisms that determine why...

متن کامل

Histone/protein deacetylases and T-cell immune responses.

Clinical and experimental studies show that inhibition of histone/protein deacetylases (HDAC) can have important anti-neoplastic effects through cytotoxic and proapoptotic mechanisms. There are also increasing data from nononcologic settings that HDAC inhibitors (HDACi) can exhibit useful anti-inflammatory effects in vitro and in vivo, unrelated to cytotoxicity or apoptosis. These effects can b...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of allergy, asthma and immunology

جلد ۱۳، شماره ۴، صفحات ۲۲۰-۲۳۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023